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Journal Club - #12

Optical Mapping of repolarization and refractoriness from intact hearts

Efimov IR, Huang DT, Rendt JM, Salama G

Circulation. 1994 Sep; 90(3):1469-80 [PubMed]

Journal Club - #11

Subthreshold stimulation of Purkinje fibers interrupts VT in intact hearts. Experimental study with voltage-sensitive dyes and imaging techniques

Salama G, Kanai A, Efimov IR

Circulation Research. 1994 Apr; 74(4):604-19 [PubMed]

Mutations leading to sudden cardiac arrest

Very powerful family story about lethal mutations leading to sudden cardiac death. Stories like this make our work on arrhythmias and development of new therapies highly meaningful. We found TRP genes remodeled in patients with end-stage heart failure, but their role in cardiac electrophysiology is not well-studied. We plan to focus on them in one of our future grant applications.

Journal Club - #10

Quantification of the transmural dynamics of atrial fibrillation by simultaneous endocardial and epicardial optical mapping in an acute sheep model

Sarah R. Gutbrod, Richard Walton, Stephen Gilbert, Valentin Meillet, Pierre Jais, Mélèze Hocini, Michel Haïssaguerre, Rémi Dubois, Olivier Bernus, Igor R. Efimov

Circ Arrhythm Electrophysiol. 2015;8:456-465. [PubMed]

Journal Club - #9

An activation-repolarization time metric to predict localized regions of high susceptibility to reentry

Nicholas Child, Martin J. Bishop, Ben Hanson, Ruben Coronel, Tobias Opthof, Bastiaan J. Boukens, Richard D. Walton, Igor R. Efimov, Julian Bostock, Yoland Hill, Christopher A. Rinaldi, Reza Razavi, Jaswinder Gill, Peter Taggart. 

Heart Rhythm 2015;12:1644-1653. [PubMed]

Journal Club - #8

The functional role of electrophysiological heterogeneity in the rabbit ventricle during rapid pacing and arrhythmias

Martin J. Bishop, Edward J. Vigmond, Gernot Plank

Am J Physiol Heart Circ Physiol 304: H1240-H1252, 2013. [PubMed]


Journal Club - #7

The role of Purkinje-Myocardial Coupling during Ventricular Arrhythmia: A modeling study

Elham Behradfar, Anders Nygren, Edward J. Vigmond

PLoS ONE. 2014 Feb 7;9(2):e88000. [PubMed]

Journal Club - #6

Processing and analysis of cardiac optical mapping data obtained with potentiometric dyes

Jacob I. Laughner, Fu Siong Ng, Matthew S. Sulkin, R. Martin Arthur, Igor R. Efimov

Am J Physiol Heart Circ Physiol 303: H753-H765, 2012 [PubMed]


Journal Club - #5

Aberrant sodium influx causes cardiomyopathy and atrial fibrillation in mice

Elaine Wan, Jeffrey Adams, Richard L. Weinberg, Alexander N. Katchman, Joseph Bayne, Sergey I. Zakharov, Lin Yang, John P. Morrow, Hasan Garan, Steven O. Marx

J Clin Invest. 2016;126(1):112-22 [PubMed]

Journal Club - #4

Fibrosis, Connexin-43, and Conduction Abnormalities in the Brugada Syndrome

Koonlawee Nademanee, Hariharan Raju, Sofia V. de Noronha, Michael Papadkis, Laurence Robinson, Stephen Rothery, Naomasa Makita, Shinya Kowase, Nakorn Boonmee, Vorapot Vitaykritsirikul, Samremg Ratanarapee, Sanjay Sharma, Allard C. van der Wal, Michael Christiansen, Hanno L. Tan, Arthur A. Wilde, Akihito Nogami, Mary N. Sheppard, Gumpanart Veerakul, and Elijah R. Behr