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Journal Club - #18

Hypoxia and hypothermia enhance spatial heterogeneities of repolarization in guinea pig hearts: analysis of spatial autocorrelation of optically recorded action potential durations.

Salama G, Kanai AJ, Huang D, Efimov IR, Girouard SD, Rosenbaum DS

J Cardiovasc Electrophysiol. 1998 Feb;9(2):164-83 [PubMed]

Journal Club - #17

Relation of the atrial input sites to the dual atrioventricular nodal pathways: crossing of conduction curves generated with posterior and anterior pacing

Tchou PJ, Cheng YN, Mowrey K, Efimov IR, Van Wagoner DR, Mazgalev TN

J Cardiovasc Electrophysiol. 1997 Oct;8(10):1133-44 [PubMed]


Journal Club - #16

Transmembrane voltage changes produced by real and virtual electrodes during monophasic defibrillation shock delivered by an implantable electrode

Efimov IR, Cheng YN, Biermann M,  Van Wagoner DR, Mazgalev TN, Tchou PJ

J Cardiovasc Electrophysiol. 1997 Sep;8(9):1031-45 [PubMed]


Journal Club - #15

Effects of 2,3-butanedione monoxide on atrial-atrioventricular nodal conduction in isolated rabbit heart

Cheng Y, Mowrey K, Efimov IR, Van Wagoner DR, Tchou PJ, Mazgalev TN

J Cardiovasc Electrophysiol. 1997 Jul;8(7):790-802 [PubMed]

Journal club - #14

High-resolution fluorescent imaging does not reveal a distinct AV nodal anterior input channel (fast pathway) in the rabbit heart during sinus rhythm

Efimov IR, Fahy GJ, Cheng Y, Van Wagoner DR, Tchou PJ, Mazgalev TN

J Cardiovasc Electrophysiol. 1997 Mar;8(3):295-306 [PubMed]

Journal Club - #13

Activation and repolarization patterns are governed by different structural characteristics of ventricular myocardium: experimental study with voltage sensitive dyes and numerical stimulations

Efimov IR, Ermentrout B, Huang DT, Salama G

J Cardiovasc Electrophysiol. 1996 Jun;7(6):512-30 [PubMed]


Journal Club - #12

Optical Mapping of repolarization and refractoriness from intact hearts

Efimov IR, Huang DT, Rendt JM, Salama G

Circulation. 1994 Sep; 90(3):1469-80 [PubMed]

Journal Club - #11

Subthreshold stimulation of Purkinje fibers interrupts VT in intact hearts. Experimental study with voltage-sensitive dyes and imaging techniques

Salama G, Kanai A, Efimov IR

Circulation Research. 1994 Apr; 74(4):604-19 [PubMed]

Mutations leading to sudden cardiac arrest

Very powerful family story about lethal mutations leading to sudden cardiac death. Stories like this make our work on arrhythmias and development of new therapies highly meaningful. We found TRP genes remodeled in patients with end-stage heart failure, but their role in cardiac electrophysiology is not well-studied. We plan to focus on them in one of our future grant applications.

Journal Club - #10

Quantification of the transmural dynamics of atrial fibrillation by simultaneous endocardial and epicardial optical mapping in an acute sheep model

Sarah R. Gutbrod, Richard Walton, Stephen Gilbert, Valentin Meillet, Pierre Jais, Mélèze Hocini, Michel Haïssaguerre, Rémi Dubois, Olivier Bernus, Igor R. Efimov

Circ Arrhythm Electrophysiol. 2015;8:456-465. [PubMed]