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Leducq Foundation funded our transatlantic network of excellence: RHYTHM!

Our transatlantic network consisting of 6 universities received funding from the Leducq Foundation. Our project is titled Repolarization HeterogeneitY imaging for personalised Therapy of Heart arrhythMia (RHYTHM). Project was among only 5 funded proposals selected from 120 submitted. Project description and participants on the Leducq Foundation web-site:

The Heart of the Matter

Since 1958, average life expectancy in the US has increased by 10 years. According to Igor Efimov, the inaugural chair of GW’s Department of Biomedical Engineering and the Alisann and Terry Collins Professor of Biomedical Engineering, the 68 percent reduction in the mortality rate from heart disease during the same period is a huge contributor to this remarkable gain in life expectancy.

That said, heart disease still remains the country’s number one killer, and Dr. Efimov has dedicated his life’s work to better understanding and developing devices to treat it.

Journal Club - #38

Phase I and phase II of short-term mechanical restitution in perfused rat left ventricles

Dumitrescu C, Narayan P, Cheng Y, Efimov IR, Altschuld RA

Am J Physiol Heart Circ Physiol. 2002 Apr;282(4):H1131-9 [PubMed]

Journal Club - #37

Imaging of the atrioventricular node using optical coherence tomography

Gupta M, Rollins AM, Izatt JA, Efimov IR

J Cardiovasc Electrophysiol. 2002 Jan; 13(1):95 [PubMed]

Journal Club - #35

Mechanisms of make and break excitation revisited: paradoxical break excitation during diastolic stimulation

Nikolski VP, Sambelashvili AT, Efimov IR

Am J Physiol Heart Circ Physiol. 2002 Feb;282(2):H565-75 [PubMed]

Journal Club - #34

The mechanisms of the vulnerable window: the role of virtual electrodes and shock polarity

Yamanouchi Y, Cheng Y, Tchou PJ, Efimov IR

Can J Physiol Pharmacol. 2001 Jan;79(1):25-33 [PubMed]

Journal Club - #32

Reversal of repolarization gradient does not reverse the chirality of shock-induced reentry in the rabbit heart

Cheng Y, Nikolski V, Efimov IR

J Cardiovasc Electrophysiol. 2000 Sep;11(9):998-1007 [PubMed]