Sharon George, PhD

Sharon George, PhD

Postdoctoral Scientist

Heart diseases and Cancer have been identified as the two leading causes of death in the United States. When the treatment of one contributes to the prevalence of the other, it poses a unique and complicated condition. My research is focused on the cardiotoxicity of highly potent anthracycline antibiotics used in cancer chemotherapy. We look at the role of stress signaling pathways that are involved in the development of cardiotoxic effects and identify methods to inhibit these pathways. This can then protect the heart during cancer therapy while allowing the administration of more efficient doses of cancer drugs. We first test the effects of these drugs in mice hearts and we then compare the observed effects to those from human cardiac organotypic slice preparations. This work can thereby significantly impact both the fields of cardiology and oncology, or as they now call it - cardiac oncology.         

  • Education 
    • B.E. - Biomedical Engineering, Anna University, Chennai, India (2007-2011)
    • PhD - Biomedical Engineering, Virginia Tech, Blacksburg, VA (2011-2016)
    • Postodoctoral Scientist, The George Washington University (2016 - Present)
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Contact information

Department of Biomedical EngineeringThe George Washington UniversityScience and Engineering Hall800 22nd Street NW Rm 5100Washington DC, 20052Email: sharonag@gwu.edu

Honors

  • American Heart Association Predoctoral Fellowship
  • Paul E Torgersen Research Excellence Award
  • VTCRI Medical Research Scholar
  • David W Francis and Lillian Francis Scholarship 

Recent publications

  • Sharon A George, Katherine J Sciuto, Joyce Lin, Mohammed Salama, James Keener, Robert G Gourdie, Steven Poelzing. Extracellular Sodium and Potassium Levels Modulate Cardiac Conduction in Mice Heterozygous Null for the Connexin43 Gene. Pflugers Archiv – European Journal of Physiology, 2015. PMID: 25771952.
  • Sharon A George, Steven Poelzing. Cardiac Conduction in Isolated Hearts of Genetically Modified Mice - Connexin43 and Salts. Progress in Biophysics and Molecular Biology, 2015. PMID: 26627143
  • Michael Entz II, Sharon A George, Michael J Zeitz, Tristan Raisch, James W Smyth, Steven Poelzing. Heart Rate and Extracellular Sodium and Potassium Modulation of Gap Junction Mediated Conduction in Guinea Pigs. Front Physiol, 2016. PMID: 26869934
  • Sharon A George, Mohammad Bonakdar, Michael Zeitz, Rafael V Davalos, James W Smyth, Steven Poelzing. Extracellular Sodium dependence of the Conduction Velocity – Calcium Relationship: Evidence of Ephaptic Self-attenuation. Am J Physiol Heart Circ Physiol, 2016. PMID: 26945081
  • Amara Greer-Short, Sharon A George, Steven Poelzing, Seth H Weinberg. Revealing the Concealed Nature of Long-QT Type 3 Syndrome. Circ Arrhythm Electrophysiol, 2017. PMID: 28213505