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Lab Meeting Weekly Update

  • Jaclyn​ ​Brennan’s​ ​Presentation​ ​Over​ ​the​ ​Article: 
    • Olivas​ ​A,​ ​Gardner​ ​RT,​ ​Wang​ ​L,​ ​Ripplinger​ ​CM,​ ​Woodward​ ​WR,​ ​Habecker​ ​BA. 

Myocardial​ ​Infarction​ ​Causes​ ​Transient​ ​Cholinergic​ ​Transdifferentiation​ ​of Cardiac​ ​Sympathetic​ ​Nerves​ ​via​ ​gp130.​ ​J​ ​Neurosci.​ ​2016​ ​Jan​ ​13;36(2):479-88. doi:​ ​10.1523/JNEUROSCI.3556-15.2016.​ ​PubMed​ ​PMID:​ ​26758839;​ ​PubMed Central​ ​PMCID:​ ​PMC4710771. 

Lab Meeting Weekly Update

  • The website (efimovlab.org) has new features! You can now see and read about our amazing staff and graduate students, and you will soon be able to read about the undergraduates working in the lab - be on the lookout!
  • Christian Micille updated the lab on some exciting news on his mouse colonies: the lab has a numerous amount of different type of mice ready to be genotyped!

Papers and projects to look out for in the future:

Lab Meeting Weekly Update

 

  • Dr. Aras presented updates on his canine AF study. 

  • Dr. Efimov shared an information research video in which a research team at the University of Wisconsin-Madison demonstrates a method for high-resolution optical mapping of the mouse sino-atrial node.

Some of the staff are in the final stages of publishing papers and projects:

  • Chaoyi Kang's IKs/IKr paper

Medical Technology of the Future

We are excited to announce the publication of our latest work in Nature Biomedical Engineering. In collaboration with the John Rogers' Lab, we validated their novel electrode design by simultaneously recording while collecting optically mapping images in an in-vitro Langendorff perfused rabbit heart. This device platform overcomes issues associated with chronic implantation of metal oxide electrodes (e.g. intrusion of biofluids into underlying electronics and current leakage).

EFIMOV LAB REPRESENTS AT GWU SEAS R&D SHOWCASE

Yesterday evening was the yearly GWU SEAS R&D Showcase. Students from all of GWU's engineering disciplines prepared posters of their work and were judged by a panel of investigators and volunteers from industry. We would like to congratulate Chris Gloschat for being awarded 3rd Place Best Experimental Poster and Jaclyn Brennan for being awarded a Runner-Up Student Travel Award!

The Heart of the Matter

Since 1958, average life expectancy in the US has increased by 10 years. According to Igor Efimov, the inaugural chair of GW’s Department of Biomedical Engineering and the Alisann and Terry Collins Professor of Biomedical Engineering, the 68 percent reduction in the mortality rate from heart disease during the same period is a huge contributor to this remarkable gain in life expectancy.

That said, heart disease still remains the country’s number one killer, and Dr. Efimov has dedicated his life’s work to better understanding and developing devices to treat it.

Mutations leading to sudden cardiac arrest

Very powerful family story about lethal mutations leading to sudden cardiac death. Stories like this make our work on arrhythmias and development of new therapies highly meaningful. We found TRP genes remodeled in patients with end-stage heart failure, but their role in cardiac electrophysiology is not well-studied. We plan to focus on them in one of our future grant applications.

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